Keynote Plenary Speakers

Keynote Plenary Speakers

Reis Rui

Professor Rui L. Reis, PhD, DSc, Hon. Causa MD, FBSE, FTERM, member of NAE, FAIMBE, FEAMBES, is the Vice-President for Research and Innovation of University of Minho, Portugal, Director of the 3B’s Research Group and of the ICVS/3B´s Associate Laboratory of UMinho. He is also the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global (World) President of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine (Wiley, IF=4.0). He is a recognized World expert, with more 1096 published works listed on ISI Web of Knowledge with an h index of 81 (1037 and h=88 in Scopus and 1760 and h=104 in Google Scholar), being also an inventor of around 60 patents. Based on those he co-funded several companies that raised important private investments. According to the later Google Scholar his work has been cited more than 44900 times. He has been awarded many important international prizes, including among several others different innovation awards, the Jean Leray and George Winter Awards (ESB), the Clemson Award (SFB) and TERMIS-EU Awards for contributions to the literature, and recently (2018) the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize. He was also awarded two honoris causa degrees by European Universities. He is the PI of projects with a budget totalizing more than 45 million Euros.
Title of the keynote presentation: “New Approaches, Combining Natural Materials and Stem Cells, for the Engineering of Different Types of Tissues”
Abstract:
The selection of a proper material to be used as a scaffold or as a hydrogel to support, hold or encapsulate cells is both a critical and a difficult choice that will determine the success of failure of any tissue engineering and regenerative medicine (TERM) strategy.
We believe that the use of natural origin polymers, including a wide range of marine origin materials, is the best option for many different approaches that allow for the regeneration of different tissues. In addition to the selection of appropriate material systems it is of outmost importance the development of processing methodologies that allow for the production of adequate scaffolds/matrices, in many cases incorporating bioactive/differentiation agents in their structures.
Furthermore an adequate cell source should be selected. In many cases efficient cell isolation, expansion and differentiation and in many cases the selection of a specific sub-population, methodologies should be developed and optimized. We have been using different human cell sources namely: mesenchymal stem cells from bone marrow, mesenchymal stem cells from human adipose tissue, human cells from amniotic fluids and membranes and cells obtained from human umbilical cords.
The development of dynamic ways to culture the cells and of distinct ways to stimulate their differentiation in 3D environments, as well as the use of nano-based systems to induce their differentiation and internalization into cells, is also a key part of some of the strategies that are being developed in our research group.
The potential of each combination materials/cells, to be used to develop novel useful regeneration therapies will be discussed. The use of different cells and their interactions with different natural origin degradable scaffolds and smart hydrogels will be described. Several examples of TERM strategies to regenerate different types of tissues will be presented. This will include the use of original high-throughput methodologies to look at materials/cell interactions.

Gultekin Goller

Prof. Dr. Gultekin Goller is a materials science professor who graduated from Istanbul Technical University in 1989 with a B.S. in Metallurgical Engineering. In 1997, he received his Ph.D. in the field of Metallurgical and Materials Engineering from Istanbul Technical University. He attended to the Tribology Group of Cleveland State University in 1995 as a UNIDO fellow. He joined to the Metallurgical and Materials Engineering Department of ITU in 1999 as an assistant professor. Professor Goller was promoted to associate professor in 2005 and became a full professor in 2010. His professional and scientific activity comprises: papers, which are cited over 1150 times (h-index:19), published in science citation index journals (97); papers published in international peer-review periodicals (7); the proceedings of international or national conferences (110); participating in different international or national research projects (48); author of several international book chapter; member of the scientific committee of different meetings; head of the organizing committee for different international conferences; member of the International Editorial Board of some journals; and reviewer for different journals.
Title of keynote presentation: “Processing of ZrC Based Composites Prepared by Spark Plasma Sintering”
Abstract:
Zirconium carbide (ZrC) is a typical ultra-high temperature ceramic, has a good combination of properties, such as high hardness (26 GPa), high melting point (3400 °C), low theoretical density (6.6 g/cm3) and high thermal conductivity (20.5 W/m.K, at 20 °C). However, low fracture toughness values and difficulties in densification limit the use of these materials. Titanium carbide (TiC) has similar mechanical properties and same crystal structure with ZrC. Moreover, a number of studies have shown that graphene nanoplatelets (GNPs) and carbon nanotube (CNT) have superior mechanical, thermal and electrical properties and they have a significant interest as a reinforcing phase thanks to these distinguishing properties. In addition to this, recent studies have demonstrated that GNP and CNT addition can dramatically change the mechanical properties of ceramic materials. In this study, TiC, GNP and CNT phases were incorporated into ZrC matrix and monolithic ZrC, ZrC-TiC binary composites, ZrC-TiC-CNT and ZrC-TiC-GNP ternary composites and ZrC-TiC-GNT(GNP an CNT) composites were produced by spark plasma sintering (SPS) at 1600-1700 °C under 40 MPa with 5 min holding time. The prepared composites were then characterized in terms of their densification, microstructure and mechanical properties. Improvement of densification behaviour and existence of different toughening mechanisms of TiC, TiC-CNT, TiC-GNP and TiC-GNT (GNP-CNT) additions will be discussed in this presentation.

Hasan Gomcez

Prof. Hasan Gocmez received his BSc degree from the Department of Metallurgical Engineering of Middle East Technical University, Turkey in 1994, and his MSc and PhD degrees in Material and Ceramic Engineering departments from the Rutgers University, New Jersey, USA in 1997 and 2001, respectively. He was awarded by Japan Society for Promotion of Science as JSPS fellows between 2006 and 2007 to do research at Yamaguchi University. He was a visiting scientist at AIST, Stockholm University, Stevens Institute of Technology and KTH. He has more than 100 publications including articles, conference proceedings and others. He is also an associate editor of Journal of the Ceramic Society of Japan and was an editor of Science and Engineering Journal of Dumlupınar University. His research focus on ceramic processing, nanomaterials and photovoltaic materials. He is Professor in the Department of Metallurgical and Materials Engineering at Kutahya Dumlupinar University. E-mail Address: hasan.gocmez@dpu.edu.tr
Title of the keynote presentation: The Preparation of Low Lead Contenting Organic-Inorganic Perovskite Solar Cells
Abstract:
Organic-inorganic perovskite solar cells with low lead content or without lead need to be studied more to have eco-friendly products for the solar market. In this study, Lead and low lead contenting organic-inorganic perovskite solar cell were prepared by two steps solution and spin coating methods to optimize the power conversion efficiency of cell. Goldschmidt’s tolerance factor used to determine which elements (Co+2, Fe+2, Ca+2 and Ge+2 etc.) can be formed stable perovskite structure that can be obtained to be closed to unity. Furthermore, Co+2 is selected due the unity of Goldschmidt’s tolerance factors, Sr+2 is recommended due to similar ionic Radius to Pb, Ca+2 that has tolerance factor near to lead based perovskite solar cell. CH3NH3Pb1-xCoxI3 and CH3NH3Pb1-xSrxI3 structure were prepared with various compositions (X=0, 0.1 and 0.3). Perovskite solar cell including Co+2 and Sr+2 instead of lead thin films were obtained only compact titanium oxide layer (TiO2). Both compact and mesoporous TiO2 layers were characterized by x-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Ultra-violet spectroscopy (UV) and solar simulators. Cell components, photoanodes prepared by spin coated and tape casting, then perovskite structure acquired with adding hole transporting materials and electrodes enclosed on top of it. Finally, cell was assembled. Electronic properties, band gap and phases of selected compositions of targeted cell components were calculated theoretically. Photovoltaic properties of cells were measured with standard characterization methods.
*This work was supported by TÜBİTAK (The Scientific and Technological Research Council of Turkey) through project number 116F073.

Dan Eliezer

Professor D.Sc., FASM, Dan Eliezer received his PhD in Materials Science and Engineering from the Technion Institute of Technology in Israel. Professor Eliezer is an ASM Fellow in recognition of distinguished contribution to the field of materials science and engineering. He was a Research Associate at the University of Illinois at Urbana-Champaign and shortly after joined the NASA-AMES Research Center. He was the Head of the Department of Materials Engineering at Ben-Gurion University and involved in highly ranked administrative committees. Professor Eliezer is especially known for his research in the field of hydrogen interaction in materials and hydrogen energy. His research work also covers physical metallurgy, environmental behavior of materials, and failure analysis. He is the recipient of many awards and fellowships. He was a National Research Council Senior Associate at the Air Force Base in Dayton, Ohio and received the American Academy of Science Fellowship during this time. He was a Senior Visiting Scientist at BAM, the Federal Institute for Materials Research in Berlin, Germany and received the prestigious Oswald Fellowship awarded to scientists who have distinguished themselves with an extraordinary scientific performance. He has been a visiting professor at a number of institutions across the United States, Europe, and Asia, receiving Doctor Honoris Causa from the University POLITEHNICA of Bucharest and Technical University “Gh. Asachi” of Iasi. Prof. Eliezer has published over 500 papers, written numerous collective volumes, and edited 9 scientific books. Prof. Eliezer has a h-index of 37 and a RG of 44.95. He is an active member in a variety of academic, research, and institutional committees. He is also active in international advisory boards for scientific, academic, and insutrial institutions.
Title of the keynote presentation: “Materials Performance in Hydrogen Environments”
Abstract:
Development and validation of a lifetime prediction methodology for failure of materials used for hydrogen containment components is of significant importance to the planned hydrogen economy. With the prospect of transitioning to a hydrogen-based economy, many engineering components will be exposed to high-pressure gaseous hydrogen environments.
This paper reviews recent contributions to the understanding hydrogen embrittlement, and the role of hydrogen in different structural materials. Hydrogen continues to be an area of interest for the oil. gas industry, and transportation.
An overview is given of our present work and understanding of materials performance in hydrogen environments. A variety of analysis methods were used in our research. Microstructure analysis was composed of ToF-SIMS, EDDI-synchotron beamline, and SEM &TEM. Hydrogen content and trapping analysis comprised of thermal desorption spectrometry (TDS), X-ray diffraction, and carrier gas hot extraction (CGTE). Strength analysis was done by quasi-static tensile loading and dynamic experiments.
Thermal desorption spectroscopy (TDS) was used to identify and quantify the types and strengths of the hydrogen trapping sites. Hydrogen trapping and diffusion will be discussed in relation with microstructure features and mechanical properties. We present a model for hydrogen transport that accounts for trapping of hydrogen at microstructural defects and addresses the interaction of hydrogen solute atoms with material deformation.
The residual stress state in a material has an important role in the mechanism of hydrogen induced cracking. The hydrogen interaction with residual stresses is studied by synchrotron x-ray diffraction. The results will be discussed in detail.

Florin Miculescu

Dr. Habil. Florin Miculescu is a Professor at the Politehnica University from Bucharest. He leads research laboratories in the Metallic Materials Science and Physical Metallurgy Department and supervises an active and dynamic group of researchers and students. He is currently teaching materials science & engineering, biomaterials characterization methods and electron microscopy & microanalysis courses.
He has participated in five postdoctoral stages in Europe and USA and applied his expertise in various research projects related to materials science, engineering, and technology (manager of 8 national and over 50 projects for private companies in the last 15 years). He is a former President of the Romanian Society for Biomaterials (2014-2017). His research activities in the fields of biomaterials, nanomaterials and materials synthesis, processing and characterization are presented in over 100 ISI-Web of Science articles (impact factor 55 as main author), 5 books and 8 book chapters.
His professional and scientific activity comprises research in the fields of biomaterials, nanomaterials, hybrid and composite materials, electron microscopy in materials science, nanosize effect and critical dimension in bioapplications, biosensing and biosensors with nanomaterials, clean and green technologies. Ongoing research is related to natural resources for calcium phosphates – bovine bone, fish bone, marble, seashells; calcium phosphates preparation, processing and sintering; hydroxyapatite/silver microcomposites; hydroxyapatite-starch interactions and hydroyapatite-polymer composites for 3D printing.
Title of the keynote presentation: “Innovative sintering additives for naturally-derived ceramics”
Abstract:
Sintering is commonly used for manufacturing ceramic products for a wide set of applications. Moreover, it has in important role in other processes such as additive manufacturing, thin films and nanotechnology. Currently, many commercial bioceramics are available in sintered form since the improvements induced by this process proved to be beneficial for osseointegration [1].
One of the main targets of a conventional sintering programme is to achieve a fine and dense microstructure; however, this is not the case for ceramic materials intended for bone reconstruction, which need to possess adequate porosity for bone regeneration and vascularization. Materials porosity could also affect the mechanical properties of the material, so these two characteristics need to be carefully balanced. Moreover, thermal treatment activate both densification and grain growth, an additional process which affects the ceramic microstructure [2, 3].
Although widely available for ceramic powders prepared by conventional routes [2], very few data related to sintering of ceramic materials prepared by processing natural materials were discussed until now. One argument against sintering of naturally-derived ceramics is their unpredictable stoichiometry and random arrangement of vacations and substitutions within the crystalline lattice, which will lead to unreliable material characteristics. However, our experiments regarding sintering of ceramics prepared by thermally treating bovine bones showed reproducible characteristics of the sintered materials.
This presentation includes recent findings [4, 5] related to choosing natural sintering additives, which are economic, efficient and biocompatible, and enhance the mechanical properties of bone-derived ceramics or provide an adequate porosity for bone reconstruction. Further initiatives regarding the development of sintered ceramic products for bone reconstruction will also be presented.
References.
[1] Sadowska, J. M. et. al. Tissue Engineering Part A, 2017, 23(23-24): 1297-1309.
[2] Champion, E., Acta biomaterialia, 2013; 9(4): 5855-5875.
[3] Rahaman, M. N., Sintering of ceramics. CRC press. 2007
[4] Miculescu, F., et. al. ACS Sustainable Chemistry & Engineering, 2017, 5(10): 8491-8512.
[5] Miculescu, F., et. al. ACS Omega, 2018, 3(1), 1338-1349.

Popa Catalin

Professor Cătălin POPA, Dr.Eng., Head of Biomaterials Research Group Technical University of Cluj-Napoca, ROMANIA catalin.popa@stm.utcluj.ro
Dr. Catalin Popa is a Professor in the Department of Materials Science and Engineering in the Faculty of Materials and Environmental Engineering, Technical University of Cluj-Napoca (TUCN), Head of Biomaterials Research Group and President of Advanced Materials, Micro and Nanotechnologies – ADMATECH Cluster. Dipl. Engineer since 1986, he worked at the beginning of his career as a design engineer in several companies, the acquired expertise being valued in the subsequent activity, in the Biomaterials research field. Member of the academic staff of TUCN since 1990, he became Doctor of Engineering in 1997 and benefited of a NATO / Royal Society Fellowship in the University of Nottingham (2000). He was involved in numerous research projects in the UK, some of them in IRC in Biomedical Materials, QMUL, and Rutherford Appleton Laboratory, STFC, together to the 27 research grants awarded by Romanian public funding bodies. He published more than 125 papers, co-authored 7 books and patented 4 inventions. The Biomaterials Research Group he leads focuses on Tissue Engineering applications, drug delivery systems and optimisation of medical implants / devices.
Title of the keynote presentation: “Drug delivery systems in 3rd generation biomaterials”
Abstract:
The recent third generation biomaterials are conceived to incorporate the means to stimulate the most appropriate cellular responses in view of regeneration / healing of tissue. Bio – interactive biomaterials are, in most cases, complex smart systems containing elements that are designed to fulfill specialized tasks as a response to the condition of the living environment they are introduced in. Examples of such means are drug delivery systems that are designed in view of enhancing the various stages of cellular activity during tissue formation or to avoid adverse effects during the healing period. Drug delivery systems were already found suitable for numerous medical applications where the classical administration methods lead to either excessive stressing of kidneys / liver / heart or to ineffectiveness. An optimal design of the multi-layered material containing the delivery system implies a controlled release vs. time / triggering mechanism, according to the drug nature and concentration. Microcapsules made of a BSA gel core and natural polyelectrolites (chitosan and k-carrageenan) with complex layer structures and various drugs content were inserted in order to induce bio-reactivity in applications such as Tissue Engineering of hard / soft tissues, smart dressing for difficult wounds or targeted chemotherapy of dispersed cancerous tumors. Interesting results were obtained for Curcumin (anti-oxidant, anti-cancer and anti-inflammatory agent), Tetracycline (antibiotic with wide spectrum against gram-negative and gram-positive bacteria, contributing also to a faster regeneration of osteoblasts, fibroblasts and other cell types in Regenerative Medicine), Growth factors (to promote the growth, organization and maintenance of cells and tissues).

Horia Iovu